Preclinical services

At Mprex, we specialize in conducting comprehensive preclinical and toxicity studies in both GLP (Good Laboratory Practice) and non-GLP preclinical laboratories. Our services encompass toxicological studies, proof of concept studies, and preclinical investigations aimed at elucidating the mechanism of action of products. The data generated from our studies are suitable for regulatory submissions worldwide, ensuring compliance with international standards.

Our expertise extends to designing preclinical studies that effectively identify lead candidates from multiple hits and optimize the formulation for enhanced efficacy. We utilize a range of animal models supported by histopathology, biomarker analysis, and mechanistic assays to provide in-depth insights into the safety and efficacy profiles of products under development.

With a commitment to scientific excellence and regulatory compliance, we offer tailored solutions to meet the specific needs of our clients in the natural product research sector. Our proficient approach to preclinical studies enables us to accelerate the development and optimization of promising therapeutic candidates, paving the way for successful translation into clinical trials and eventual market approval.

IN VITRO & IN VIVO TECHNIQUES

Preclinical trials, including in vitro and in vivo studies, assess drug safety, efficacy, and mechanisms before human trials, ensuring regulatory compliance and optimizing dosage for efficient drug development.

In vivo studies

Neuro-behavioral Activity in Rodent
Anti-Inflammatory & Antioxidant Activity in Rodent Model
Diabetes, cardiovascular diseases related models
Liver Disease - NASH Model in Mice
Liver Disease - Paracetamol-induced acute hepatotoxicity model in mice
Assessment of Aging Markers in Rat Model
Cartilage regeneration and arthritis models in rats

Toxicological studies

Acute oral toxicity study (OECD 425)
28-day repeat dose oral toxicity study (OECD 407)
90-day repeat dose oral toxicity study (OECD 408)
In-vitro Chromosomal Aberration Test (OECD 473)
In vitro Mammalian Cell Gene Mutation Assay on L5178Y Mouse Lymphoma cells TK+/- with test item (OECD 490)
Teratogenicity study (OECD 414)

At our company, we collaborate closely with clients to design and execute preclinical studies tailored to their specific needs and research objectives. Whether utilizing in vitro or in vivo techniques, we prioritize scientific rigor, transparency, and regulatory compliance to deliver high-quality data that drive informed decision-making and advance natural product research.